WARNINGS: Individual ticks may attach or individual sand flies or mosquitoes may bite the dog. Therefore, under particularly unfavorable conditions, it is not possible to completely exclude the transmission of pathogens through these arthropods. Individual ticks may attach to the dog and detach within the first 24 hours of infestation, and it is possible that not all ticks will be eliminated within 48 hours of treatment if they are already present at the time of product application. Immediate protection against sand fly bites is not documented. To reduce the risk of infection from Leishmania infantum transmitted by sand flies (Phlebotomus perniciosus), treated dogs must be kept in a protected environment during the first 24 hours after initial application. The product maintains efficacy against fleas when treated animals are subjected to occasional immersion in water (e.g., swimming, bathing). However, it is recommended not to wash or allow dogs to swim within 48 hours after treatment. Avoid frequent bathing or washing of treated dogs, as this may negatively affect the maintenance of the product’s efficacy. To reduce reinfestations due to the appearance of new fleas, it is recommended to treat all cohabiting dogs. Other animals living in the same household should also be treated with an appropriate product. Additionally, to further reduce environmental infestation, targeted environmental treatment against adult fleas and their larval stages is recommended. In the absence of specific studies, the use of the product in dogs under 8 weeks of age or weighing less than 2 kg is not recommended. Care should be taken to avoid contact of the veterinary medicine with the dog’s eyes. It is important to ensure that the product is applied in an area where the animal cannot lick itself and to ensure that other animals do not lick the treated area after application. Due to the particular physiology of cats that prevents them from metabolizing certain compounds, including permethrin, the product may cause potentially fatal seizures in this species. In case of accidental skin exposure, wash the cat with shampoo or soap and seek veterinary care promptly. To prevent accidental exposure of cats to the product, separate treated dogs from cats until the application site is dry. It is important to ensure that cats do not lick the application site of a dog that has been treated with this product. In case of such exposure, seek veterinary care immediately. Do not use in cats and rabbits. Special precautions for those administering the veterinary medicine to animals: this product may cause skin and eye irritation, so avoid contact with skin and eyes. Do not open the pipette facing the face or near it. In case of eye exposure or if the eyes become irritated during administration, rinse them immediately with plenty of water. If eye irritation persists, consult a doctor. In case of skin exposure or if the skin becomes irritated during the administration of the product, wash the skin thoroughly immediately with water and soap. If skin irritation persists or recurs, consult a doctor. People with known hypersensitivity to fipronil and/or permethrin should avoid contact with the product. The product is harmful if ingested. Avoid hand-mouth contact. Do not smoke, drink, or eat during application. Wash hands after use. In case of ingestion, if feeling unwell, rinse the mouth and consult a doctor. Since exposure to significant doses of the excipient N-methylpyrrolidone may induce fetotoxicity and teratogenicity, pregnant women should wear gloves to avoid contact with the product. Do not touch treated animals until the application site is dry and do not allow children to play with treated animals until the application site is dry. It is therefore recommended not to treat animals during the day but to treat them in the early evening hours and not to allow recently treated animals to sleep with owners, especially with children. Store the pipettes in the original blister and, after use, empty pipettes must be disposed of immediately to prevent further access. Other precautions: the product may have negative effects on aquatic organisms. Do not allow treated dogs to enter watercourses for 2 days after treatment. Overdose: safety has been demonstrated with doses up to 5 times the maximum dose in healthy adult dogs (treated up to 3 times at monthly intervals) and in puppies (eight weeks old treated once). Known side effects may include mild neurological disturbances, vomiting, and diarrhea. These effects are transient and generally resolve without treatment within 1-2 days. The risk of adverse reactions may increase in the case of overdose, so animals should always be treated with the correct pipette size corresponding to their body weight.