WARNINGS: Avoid contact with the animal’s eyes. Other cohabiting animals must also be treated with an appropriate product. Special precautions for use in animals: it is important that the product is applied in an area where the animal cannot lick itself and to ensure that animals do not lick each other after treatment. In cats and ferrets, there is no information on how immersion in water or baths may interfere with the product’s activity. However, based on data obtained from dogs washed starting 2 days after application, it is recommended to avoid bathing for 2 days after application. Individual ticks may attach to the cat. For this reason, under unfavorable conditions, the transmission of infectious diseases cannot be completely excluded. Fleas present on animals often infest the animal’s basket, blankets, and areas where the animal lives, particularly carpets, curtains, and upholstery; these should be treated with a suitable insecticide and regularly cleaned with a vacuum cleaner in case of massive infestations and at the beginning of anti-parasitic treatment. The potential toxicity of Frontline Combo Spot-On for cats in kittens under 8 weeks of age in contact with a treated mother is not documented. Special precautions to be taken by the person administering the veterinary medicine to the animals: the product may cause irritation to mucous membranes, skin, and eyes. Therefore, avoid contact with the mouth, skin, and eyes. People with known hypersensitivity to insecticides or alcohol should avoid contact with the product. Avoid letting the contents come into contact with hands. In case of accidental contact with eyes, rinse thoroughly with water. Wash hands after use. Do not touch treated animals and do not let children play with treated animals until the application site is dry. It is therefore recommended not to treat animals during the day, but to treat them in the evening and, if just treated, not to let them sleep with the owners, particularly with children. Do not smoke, drink, or eat during application. The risk of side effects may increase in case of overdose. In cats: in safety studies, no side effects were observed in cats and kittens 8 weeks and older weighing about 1 kg, treated once a month at doses five times higher than the recommended dose for six consecutive months. Itching may occur following treatment. Applying a dose higher than recommended results in a wet and sticky appearance of the fur at the application site. However, if this occurs, it will disappear within 24 hours of application. In ferrets: in ferrets 6 months and older treated every 2 weeks for four times, at doses five times higher than the recommended dose, a decrease in body weight was observed in some subjects. No known incompatibilities. THERAPEUTIC CATEGORY: Ectoparasiticides for topical use, including insecticides. STORAGE: Store below 30 degrees C. Keep in the original packaging. Shelf life of the veterinary medicine packaged for sale: 36 months. CONTRAINDICATIONS/ADVERSE EFFECTS: In the absence of data, do not use the product in kittens under 8 weeks of age and/or weighing less than 1 kg. Do not use the product in ferrets under 6 months of age. Do not use in sick animals (e.g., systemic diseases, fever) or convalescent animals. Do not use in rabbits, as potentially fatal adverse reactions may occur. In the absence of studies, it is recommended not to use the product in species other than those intended. Do not use in cases of hypersensitivity to the active ingredients or to any of the excipients. NAME: FRONTLINE COMBO SPOT-ON CATS. DIAGNOSIS AND PRESCRIPTION: The sale is not exclusively reserved for pharmacies and is not subject to a veterinary prescription requirement. EXCIPIENTS: Butylhydroxytoluene (E321), ethanol, polysorbate 80 (E433), povidone, monoethyl ether of diethylene glycol. UNDESIRABLE EFFECTS: Do not exceed the recommended dose. Among the extremely rare suspected adverse reactions, transient skin reactions at the application site (scaling, local hair loss, itching, redness) and generalized itching or hair loss after application have been described. Hypersalivation, reversible neurological symptoms (increased sensitivity to stimuli, lethargy, other nervous symptoms), or vomiting have also been observed. If animals lick themselves, transient hypersalivation may be observed mainly due to the excipients of the product. The frequency of adverse reactions is defined using the following conventions: very common (more than 1 in 10 treated animals exhibit adverse reactions); common (more than 1 but less than 10 animals out of 100 treated); uncommon (more than 1 but less than 10 animals out of 1,000 treated); rare (more than 1 but less than 10 animals out of 10,000 treated); very rare (fewer than 1 animal out of 10,000 treated, including isolated reports). PREGNANCY AND LACTATION: In cats: the product can be used during pregnancy. For treatment during lactation, see paragraph 4.5. In ferrets: laboratory studies in cats have not produced any evidence of teratogenic, fetotoxic, or maternal toxic effects. The safety of the veterinary medicine during pregnancy and lactation in ferrets has not been established. Use only according to the risk/benefit assessment of the responsible veterinarian. INDICATIONS: In cats: to be used against flea infestations, alone or in association with ticks and chewing lice. Eliminates fleas (Ctenocephalides spp.). The insecticidal activity against new infestations of adult fleas persists for 4 weeks. Prevents the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), pupae, and larvae (larvicidal activity) born from eggs laid by adult fleas, for 6 weeks after application. Eliminates ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). The product has tick activity lasting up to 2 weeks (based on experimental data). Eliminates chewing lice (Felicola subrostratus). Frontline Combo Spot-on for Cats can be used in the program for controlling Flea Allergy Dermatitis (FAD). In ferrets: to be used against flea infestations, alone or in association with ticks. Eliminates fleas (Ctenocephalides spp.). The insecticidal activity against new infestations of adult fleas persists for 4 weeks. Prevents the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), pupae, and larvae (larvicidal activity) born from eggs laid by adult fleas. Eliminates ticks (Ixodes ricinus). The product has acaricidal activity against ticks lasting for 4 weeks (based on experimental data). INTERACTIONS: No known interactions. DOSAGE: For external use only. Spot-on application. One 0.5 ml pipette for cats, corresponding to the minimum recommended dose of 5 mg/kg of fipronil and 6 mg/kg of (S)-methoprene, for topical application. In the absence of safety data, the minimum treatment interval should be 4 weeks. One 0.5 ml pipette for ferrets, corresponding to 50 mg of fipronil and 60 mg of (S)-methoprene, for topical application. The minimum treatment interval should be 4 weeks. Administration method: hold the pipette upright and gently tap the narrow part of the pipette so that the liquid remains in the wide part of the pipette. Break the pre-cut tip. Part the hair at the base of the neck, on the back of the animal, between the shoulder blades, and expose the skin. Place the tip of the pipette on the skin and squeeze the pipette several times until completely empty, applying the product in one spot directly onto the skin. ACTIVE INGREDIENTS: Each 0.5 ml pipette contains: fipronil 50.00 mg, (S)-methoprene 60.00 mg, butylhydroxytoluene (E321) 0.10 mg, butylhydroxyanisole (E320) 0.05 mg. For the complete list of excipients, see paragraph 6.1. SAFETY IN TARGET SPECIES: The risk of side effects may increase in case of overdose. In cats: in safety studies, no side effects were observed in cats and kittens 8 weeks and older weighing about 1 kg, treated once a month at doses five times higher than the recommended dose for six consecutive months. Itching may occur following treatment. Applying a dose higher than recommended results in a wet and sticky appearance of the fur at the application site. However, if this occurs, it will disappear within 24 hours of application. In ferrets: in ferrets 6 months and older treated every 2 weeks for four times, at doses five times higher than the recommended dose, a decrease in body weight was observed in some subjects. TARGET SPECIES: Cats and ferrets. WAITING TIME: Not applicable. USE/METHOD OF ADMINISTRATION: For external use only.