WARNINGS
All dogs in the household must be treated. Household cats should only be treated with a veterinary medicine authorized for use in that species. Fleas can infest the dog’s bed, kennel, and usual resting areas such as carpets, sofas, and armchairs. In case of a heavy flea infestation and at the beginning of control measures, these areas should be treated with an appropriate insecticide and then cleaned regularly with a vacuum cleaner. This veterinary medicine in cats may induce seizures that can be fatal, due to the particular physiology of this species which cannot metabolize certain compounds, including permethrin. In case of accidental exposure, if adverse effects appear, wash the cat with shampoo or soap. To prevent cats from accidentally coming into contact with this veterinary medicine, keep cats away from treated dogs until the application site is dry. It is important to ensure that cats do not rub against the application site of a dog that has been treated with this veterinary medicine. The safety of this veterinary medicine has not been proven in dogs under 7 weeks of age or weighing less than 1.5 kg. Care should be taken to avoid contact between this veterinary medicine and the dog’s eyes. The attack of a single tick after treatment cannot be excluded. For this reason, the transmission of infectious diseases cannot be completely ruled out if conditions are favorable. The veterinary medicine remains effective when treated animals are immersed in water (e.g., when swimming or bathing). Repeated immersion in water weekly for a month starting 48 hours after treatment, as well as shampooing 2 weeks after treatment, does not affect the effectiveness of this product. However, the duration of effectiveness may be reduced in case of frequent shampooing or bathing within 48 hours after treatment. Special precautions for those administering the product to animals: do not eat, drink, or smoke when handling the veterinary medicine. Wash hands thoroughly and immediately after use. This veterinary medicine causes irritation to the eyes and skin. Avoid contact with the skin. In case of accidental spillage on the skin, wash immediately with soap and water. If the veterinary medicine accidentally comes into contact with the eyes, they should be thoroughly rinsed with water. If irritation to the eyes or skin persists, or if the veterinary medicine is accidentally ingested, seek medical attention immediately showing the package leaflet or label. Individuals with known hypersensitivity to any of the components should avoid contact with the veterinary medicine. Children should not touch treated dogs for at least four hours after administration of the veterinary medicine. It is therefore advisable to treat dogs in the evening or before taking them for a walk. On the day of treatment, treated dogs should not be allowed to sleep with their owners, especially if children are present. Used applicators should be disposed of immediately and not left in sight and reach of children. Wait for the application site to dry before allowing treated dogs to come into contact with fabrics or objects. Other precautions: treated dogs should not be allowed to enter watercourses for 48 hours after treatment to avoid adverse reactions to aquatic organisms. Overdose: except for erythema and changes in coat appearance, no adverse reactions have been observed in healthy puppies aged 7 weeks, treated topically 7 times at intervals of 2 weeks and up to 5 times the maximum recommended dosage. In case of accidental ingestion at the maximum recommended dosage, vomiting, salivation, and diarrhea may occur, but these should resolve without treatment. Incompatibility: do not mix with other veterinary medicines and do not apply together with other veterinary medicines simultaneously and at the same site.
PHARMACEUTICAL CATEGORY
Ectoparasiticides for topical use.
STORAGE
This veterinary medicine does not require any special storage conditions.
CONTRAINDICATIONS/ADVERSE EFFECTS
Do not use in case of hypersensitivity to one or more active ingredients or to any of the excipients. Do not use on cats. Due to their particular physiology and inability to metabolize permethrin, this veterinary medicine should not be used on cats. If applied to a cat, or ingested by a cat that has actively rubbed against a recently treated dog, this veterinary medicine may cause severe harmful reactions.
NAME
VECTRA 3D
EXCIPIENTS
N-octyl-2-pyrrolidone, N-methylpyrrolidone.
ADVERSE EFFECTS
Very rarely reported (less than 1 animal in 10,000 animals, including isolated reports) erythema, itching, or other transient signs of discomfort at the application site that usually resolve spontaneously within 24 hours after administration of the product. Very rarely gastrointestinal symptoms such as vomiting or diarrhea have also been reported. Very rarely transient aesthetic effects (greasy appearance, matted fur, and accumulations) at the application site have been reported, however, these effects are usually no longer visible after 48 hours.
PREGNANCY AND LACTATION
The safety of the veterinary medicine in bitches has not been established during pregnancy and lactation. The use of the veterinary medicine in pregnant and lactating bitches or in dogs intended for breeding should be based on the assessment of the risk/benefit ratio. Laboratory studies, with each of the components, dinotefuran, pyriproxyfen, or permethrin, in rats and rabbits did not show maternal toxic, teratogenic, or fetotoxic effects. It has been shown that dinotefuran crosses the blood-mammary barrier and is excreted in milk. N-methylpyrrolidone, an excipient of the veterinary medicine, has shown teratogenicity in laboratory animals.
INDICATIONS
Fleas: treatment and prevention of flea infestation (Ctenocephalides felis and Ctenocephalides canis). The treatment prevents flea infestation for one month. It also prevents the multiplication of fleas for two months after application by inhibiting the hatching of eggs (ovicidal activity) and inhibiting the emergence of adults from eggs laid by adult fleas (larvicidal activity). The veterinary medicine can be used as part of a treatment strategy for flea allergy dermatitis (FAD). Ticks: the veterinary medicine has persistent acaricidal efficacy and repellent action against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for one month, and Dermacentor reticulatus for up to three weeks). If ticks are present when the veterinary medicine is applied, they may not all be killed within the first 48 hours but may die within a week. To remove ticks, it is recommended to use a specific tick removal device. Sandflies, mosquitoes, and flies: the treatment provides persistent repellent activity (anti-feeding). It prevents bites from sandflies (Phlebotomus perniciosus), mosquitoes (Culex pipiens, Aedes aegypti), and flies (Stomoxys calcitrans) for one month after application. The treatment also provides persistent insecticidal activity for one month against mosquitoes (Aedes aegypti) and flies (Stomoxys calcitrans).
INTERACTIONS
None known.
DOSAGE
The minimum recommended dose is 6.4 mg dinotefuran/kg body weight, 0.6 mg pyriproxyfen/kg body weight, and 46.6 mg permethrin/kg body weight, equivalent to 0.12 ml of the veterinary medicine per kg of body weight. Use the appropriate packaging based on the animal’s body weight. Care should be taken to apply the veterinary medicine only to intact skin. Avoid superficial application to the dog’s coat. Treatment scheme: following a single application, the veterinary medicine will prevent infestation for one month. Treatment can be repeated once a month.
ACTIVE INGREDIENTS
Dinotefuran, pyriproxyfen, permethrin.
TARGET SPECIES
Dogs.
WITHDRAWAL TIME
Not applicable.
USE/ROUTE OF ADMINISTRATION
Topical.